Oxidative stress in skeletal muscle

Publisher: Birkhäuser Verlag in Basel, Boston

Written in English
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  • Muscles -- Pathophysiology,
  • Oxidative stress -- Pathophysiology

Edition Notes

Includes bibliographical references and index.

Statementedited by A.Z. Reznick ... [et al.].
SeriesMolecular and cell biology updates
ContributionsReznick, A. Z. 1945-
LC ClassificationsRC925.6 .O95 1998
The Physical Object
Paginationp. cm.
ID Numbers
Open LibraryOL347229M
ISBN 103764358203, 0817658203
LC Control Number98006332

  Whereas oxidative stress, mitochondrial damage, or core formation may definitely contribute to reduce muscle strength reported in Figure 1, we cannot rule out the possibility that the impaired force output observed in CASQ1 KO muscle is still primarily due to the altered SR Ca 2+ buffer and content and reduced Ca 2+ release from RYRs [].   Studies investigating effects of AGE/RAGE axis activation on skeletal muscle oxidative stress / metabolism are more limited. Methods and Results We tested whether high fat feeding (HFD) would alter circulating AGE concentration, skeletal muscle AGE accumulation, and oxidative stress in wild type and RAGE deficient mice. The levels and consequences of mitochondrial oxidative stress seem to be more deleterious in skeletal muscle. This effect is secondary to: (a) inhibition of electrons flow at the levels of respiratory complexes I, II, and III, and (b) decrease in the levels of CoQ10 due to inhibition of the mevalonate pathway.   Duchenne muscular dystrophy (DMD) is a lethal X-linked muscle wasting disorder caused by the absence of dystrophin, a large cytoskeletal muscle protein. Increasing the levels of the dystrophin-related-protein utrophin is a highly promising therapy for DMD and has been shown to improve pathology in dystrophin-deficient mice. One contributing factor to muscle wasting in DMD is mitochondrial.

  To elucidate the contribution of oxidative stress to muscle degeneration and the efficacy of antioxidant treatment for sarcopenia using an animal model of neurogenic sarcopenia. Summary of Background Data. Oxidative stress has been reported to be involved in a number of pathologies, including musculoskeletal disorders. The chronic interaction of this cytokine with its receptors resulted in catabolic response, as loss of muscle mass and contractile dysfunction. TNF- α promotes loss of muscle protein associated to oxidative stress signaling that culminates in muscle wasting mediated by the NF-κB activation, a redox sensitive transcription factor. Oxidative stress is a key feature in the pathophysiology of sickle cell disease. Endurance training has been shown to reduce oxidative stress in the heart and the liver of sickle mice. However, the effects of endurance training on skeletal muscles, which are major producers of reactive oxygen species during exercise, are currently unknown. The aim of this study was to evaluate the effect of. Its in-vitro efficacy was re-validated in vivo by supplementation of TCE at a dose of mg/kg/p.o. for 30 days in denervated mice model of skeletal muscle atrophy. Effects of TCE administration on levels of oxidative stress, inflammatory markers and proteolysis were determined.

Oxidative stress can be pathological. Now researchers report that the other end of the redox spectrum, reductive stress, is also pathological. Reductive stress causes pathological heart. The underlying factors leading to vascular and skeletal muscle dysfunction are unknown, but have been linked to increases in oxidative stress. Additionally, there is a lack of understanding of how vascular function is impacted by inactivity in humans and how these changes are related to skeletal muscle . With age, skeletal muscle can accumulate oxidative stress, which can cause issues such as a reduction in force generation and muscle atrophy. Muscle atrophy contributes to progressive weakness and an increased risk of mobility impairment, falls and physical frailty in .   Finally, by presenting unresolved issues related to oxidative stress and muscle atrophy, we hope that this review will serve as a stimulus for new research in this exciting field. Antioxid. Redox Signal. 15, –

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Skeletal muscle consumes significant amounts of oxygen, and its oxygen flux increases significantly under conditions of exercise and muscle contraction. This makes the muscle vulnerable to oxidative s Oxidative Stress in Skeletal Muscle | SpringerLink Skip to. Skeletal muscle consumes significant amounts of oxygen, and its oxygen flux increases significantly under conditions of exercise and muscle contraction.

This makes the muscle vulnerable to oxidative stress since concomitantly with the increase of oxygen flow there is an increase of free oxygen radicals which are a byproduct of muscle : Paperback.

Skeletal muscle consumes significant amounts of oxygen, and its oxygen flux increases significantly under conditions of exercise and muscle contraction.

This makes the muscle vulnerable to oxidative stress since concomitantly with the increase of oxygen flow there is an increase Oxidative stress in skeletal muscle book free oxygen radicals which are a byproduct of muscle respiration.

Summary: "Oxidative Stress in Skeletal Muscle brings together for the first time the most up-to-date research findings in the field."--BOOK JACKET. "A number of studies in the last decade have documented the involvement of oxygen free radicals in exercising muscles.

The term oxidative stress as it related to oxidative damage to cells and tissues was coined by Helmut Sies and colleagues in the s (for historical review, see Sies, ) and is defined as “a disturbance of the prooxidant-antioxidant environment in favor of the former” (Sies, ).Author: M.J.

Jackson, N. Pollock, C.A. Staunton, C. Stretton, A. Vasilaki, A. McArdle. Get this from a library. Oxidative stress in skeletal muscle. [A Z Reznick;] -- Skeletal muscle consumes significant amounts of oxygen, and its oxygen flux increases significantly under conditions of exercise and muscle contraction.

This makes the muscle vulnerable to oxidative. The present book chapter summarizes the most relevant findings related to redox alterations in sarcopenia.

Other than reporting the effect of oxidative stress on skeletal muscle, modifications in specific redox-sensitive cellular signaling are described. Special Issue "Oxidative Stress in Skeletal Muscle". A special issue of Antioxidants (ISSN ).

This special issue belongs to the section " Health Outcomes of Antioxidants and Oxidative Stress ". Deadline for manuscript submissions: 31 October   The increased signal intensity (SI) of 3-CP in vivo is considered to represent an oxidative stress state 6.

Therefore, in the present study, we evaluated local oxidative stress in. Oxidative stress, the imbalance between pro‐oxidant generation and antioxidant defence, has been implicated in pathological conditions of skeletal muscle, including sarcopenia, denervation, 4, 5 and cancer cachexia.

6 Excess levels of reactive oxygen species (ROS) impair Oxidative stress in skeletal muscle book function of skeletal muscle 7 and activate proteases.

The role of ROS and antioxidant enzymes in skeletal muscles is well confirmed not only during their physiological activity, but also during excessive exercising (Gomez-Cabrera et al.

), muscle fatigue (Powers et al. ) or aging-induced muscle wasting (Fulle et al. ).In this review we will focus, however, on the role of oxidative stress during skeletal muscle regeneration after injury.

Characterizes oxidative stress within the framework of redox biology, redox signaling, and medicine. Empowers researchers and students to quantify specific reactants noninvasively, identify redox biomarkers, and advance translational studies.

Oxidative Stress in Skeletal Muscle Oxidative Stress in Skeletal Muscle Bartosz, Grzegorz Academic Press Article No. cbir Oxidative Stress in Skeletal Muscle Edited by A. Renik, L. Packer, Sen et al.

Birkhauser, Verlag, Basle,Pp. Sw Fr. ISBN This book is an interesting introduction to and at the same time a competent. Easy Webs Oxidative Stress in Skeletal Muscle PDF books - Find our Lowest Possible Price. PDF Files Of Books for Sale. Narrow by Price. Research. Shop. Save. Search Millions of Items.

Shop by Department. Types: Shopping, Research, Compare & Buy Oxidative Stress in Skeletal Muscle. Oxidative Stress in Skeletal Muscle by A Z Reznick,available at Book Depository with free delivery worldwide. Reactive oxygen species (ROS) can reduce lean body mass by stimulating the expression and activity of skeletal muscle protein degradation pathways.

These compounding factors of oxidative stress may ultimately lead to muscle wasting and may cause muscular diseases such as dystrophy, myopathy, soreness, and cramps. Title: Oxidative Stress and Skeletal Muscle Dysfunction with Aging VOLUME: 4 ISSUE: 2 Author(s):Wataru Aoi and Kunihiro Sakuma Affiliation:Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, KyotoJapan.

Keywords:Aging, skeletal muscle, atrophy, oxidative stress, reactive oxygen species, antioxidant, Xanthine oxidase. Because of recent advances in the field of exercise and oxidative stress, this is an appropriate time to summarize some of the major principles of exercise-induced oxidative stress and its impact on skeletal muscle function.

Our approach will be to provide a critical synopsis of major concepts rather than a detailed analysis of data.

Effects of Starvation on Antioxidant-Related Signaling Molecules, Oxidative Stress, and Autophagy in Juvenile Chinese Perch Skeletal Muscle Author: Wu, Ping, reactive oxygen species, skeletal muscle, superoxide dismutase.

This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.

Indeed, it is possible that oxidative stress in inactive skeletal muscle may be due to the interaction of several major oxidant production pathways, including xanthine oxidase production of superoxide, nitric oxide synthase production of nitric oxide, NADPH oxidase-mediated production of superoxide, and mitochondrial production of superoxide (7, 23, 37, 38, 50, 86; Fig.

Abstract. The purpose of this study was to investigate the effects of acacia polyphenol (AP) supplementation on exercise-induced oxidative stress in mouse liver and skeletal muscle. Plasma aspartate aminotransferase (AST), liver and skeletal muscle levels of thiobarbituric acid reactive substance (TBARS), and levels of skeletal muscle protein carbonyls increased immediately after.

Skeletal Muscle Aging: Influence of Oxidative Stress and Physical Exercise Skeletal muscle abnormalities are responsible for significant disability in the elderly. Sarcopenia is the main alteration occurring during senescence and a key public health issue as it predicts frailty, poor quality of life, and by: In this study, the acute oxidative stress induced changes in nicotinamide adenine dinucleotides in mouse skeletal muscles are studied in vitro using Raman spectroscopy.

Mammalian skeletal muscles are rich in nicotinamide adenine dinucleotides in both reduced (NADH) and oxidized (NAD) states, as they are sites of aerobic and anaerobic respiration.

The oxidative stress package includes ways to find out about your oxidative stress levels and how to address them. All of my consultation packages use my proprietary approach to wellness. Alternatively, if you want to get started reducing oxidative stress on your own, the Stress Remedy Programs (7-day and day) are perfectly designed to.

Specifically, oxidative stress can lead to atrophy by activating autophagy pathways through forkhead transcription factor (FoxO) 3-mediated transcription factors, Atrogin-1 and muscle ring finger protein 1 (MuRF-1) [9, 10]. Oxidative stress may also affect skeletal muscle through the myostatin pathway.

Oxidative stress is an imbalance between free radicals and antioxidants in your body. Free radicals are oxygen-containing molecules with an uneven number of g: skeletal muscle. Oxidative stress and inflammation are two main molecular mechanisms involved in muscle atrophy.

In the current study, we want to explore whether and how salidroside, with antioxidant and anti-inflammatory properties, protects against skeletal muscle atrophy induced by denervation. Oxidative stress promotes protein degradation and apoptosis in skeletal mus-cle undergoing atrophy.

We aimed to determine whether spinal cord injury leads to changes in oxidative stress, antioxidant capacity, and apoptotic signal-ing in human skeletal muscle during the first year after spinal cord injury. Mitochondrial oxidative stress is a complex phenomenon that is inherently tied to energy provision and is implicated in many metabolic disorders.

Exercise training increases mitochondrial oxidative capacity in skeletal muscle yet it remains unclear if oxidative stress plays a role in regulating these adaptations. We demonstrate that the chronic elevation in mitochondrial oxidative stress.

Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN Article (PDF Available) in Molecular Metabolism May .Abstract. Purpose: This review provides a current perspective on the mechanism of vitamin D on skeletal muscle function with the emphasis on oxidative stress, muscle anabolic state and muscle energy metabolism.

It focuses on several aspects related to cellular and molecular physiology such as VDR as the trigger point of vitamin D action, oxidative stress as a consequence of vitamin D deficiency.Chemotherapy-Induced Weakness and Fatigue in Skeletal Muscle: The Role of Oxidative Stress Antioxidants & Redox Signaling, Vol.

15, No. 9 Role of superoxide-nitric oxide interactions in the accelerated age-related loss of muscle mass in mice lacking Cu,Zn superoxide dismutase.